Effect of Propofol Concentration on Mean Arterial Pressure and Success of Laryngeal Mask Airway Insertion: A Quasi Experimental Study

Abstract

Background and Objective: Propofol effectively suppresses airway reflexes for supraglottic device
insertion but can impact hemodynamic stability, particularly mean arterial pressure. In controlled infusions,
Propofol provides good clinical outcomes with advantages of low dose requirement, short recovery time, and
decreased incidence of adverse effects. This study aimed at comparing the frequency of successful attempts
of Laryngeal Mask Airway (LMA) insertion and the effect on Mean Arterial Pressure (MAP) of two different
target concentrations of propofol in blood given by TCI pump.
Methods: A total of 80 patients of both genders undergoing minor surgery were included in this quasiexperimental study, which was carried out in the operating rooms of the general surgery, at the department of
anesthesia, Mayo Hospital, Lahore from June 2021 to January 2022. Patients in Group Areceived propofol to
achieve a blood concentration of 6 µg/ml, while those in Group B received propofol to reach a blood
concentration of 8 µg/ml. The number of successful attempts and mean arterial pressures were noted in the
two defined groups.
Results: Mean arterial pressure was higher in Group A(96.98 ± 2.03 mmHg) compared to Group B (92.54 ±
1.79 mmHg) five minutes after achievement of target blood concentration of propofols, with a p-value of
<0.0001, and with no significant difference in the number of successful attempts of LMA insertion between
two groups.
Conclusion: Alower concentration of propofol administered via TCI is associated with a significantly lower
drop in MAP compared to a higher concentration, without compromising the frequency of successful LMA
insertion.
Key Words: Laryngeal mask airway, Mean arterial pressure, propofol, success of insertion, Target controlled
infusion