Frequency of Bone Marrow Involvement in Pyrexia of Unknown Origin

Abstract

Abstract
Background and Objectives: This study has been conducted to highlight the frequency of involvement;
bone marrow in Pyrexia of unknown origin (PUO) and delineate the existing spectrum of diseases involved,
PUO. Theresults would facilitate the clinician in making the right choice of patient for bone marrow biopsy.
Methods: A total 121 cases of pyrexia of unknown origin were included in the study. Patients with knoy:
systemic illness, hematological disorders, who had taken radiotherapy or chemotherapy or with knosmalignant disorders were excluded to avoid selection bias, Bone marrow was aspirated from posterior il
crest in all the patients along with trephine biopsy using disposable trephine biopsy needle of 11 gaug:
Wright-Geimsa stain was used to stain the smears prepared from concentrated marrow cells. T,
involvement of bone marrow was categorized into four major etiologies of PUO and assessed by obsening
bonemarrow aspirate along with trephine biopsy slides using light microscopy.
Results: The mean age was 34.72 + 14.66 years with minimum and maximum age 18 and 65 years. .Outof
121 patients. a total of 94 (77.7%) cases showed involvement of bone marrow and 27(22.3%) cases showi
noinvolvement. Poststratification Chi-square test revealed significant. P-value: 0.000.
Conclusion: Ourresults identified a large number of cases of PUO with involvement of bone marrow which
can serve as a diagnostic aid in further workup. We believe that implementing invasive procedures sucha
bone marrow biopsy can help to find the underlying cause and prevent the delay in diagnosis of such patients