Antibiotic Resistance Patterns of Escherichia Coli in Urinary Tract Infections at a Tertiary Care Hospital in Mughalpura, Lahore
DOI:
https://doi.org/10.59058/5zw83274Keywords:
Urinary tract infections, E. Coli, Sensitivity patternAbstract
Background and objective: As a chronic nosocomial and community-acquired infections, Escherichia coli (E. coli) has become a major global health concern. Finding the pattern of antibiotic susceptibility in Escherichia coli isolated from urine specimens was the aim of the current study.
Methods: It was descriptive Cross-Sectional study conducted at Shalamar Teaching Hospital in Lahore in the Micro-biology section of the Pathology Department from June 1st, 2020 to November 30th, 2020. Patients exhibiting symptoms and indications of urinary tract infections (UTIs) had urine samples taken. The samples were processed on the Cystine Lysine Electrolyte-Deficient (CLED) Agar and identified as E. coli by biochemical profile. Antibiogram of E. coli was determined by Kirby-Bauer method.
Results: A total of 165 E. coli isolates were available for analysis.. Among the tested antibiotics, Colistin exhibited the highest sensitivity of 164(99.4%), followed by Fosfomycin 156(94.5%), Imipenem 153 (92.7%), and Meropenem 150(90.9%). Nitrofurantoin demonstrated a sensitivity of 141(85.5%), while Gentamicin had a sensitivity of 110(66.7%). Piperacillin/Tazobactam, Cotrimoxazole, Ceftriaxone and Cefotaxime, Ciprofloxacin, Cefuroxime, Amoxicillin-Clavulanic Acid, and Ampicillin exhibited sensitivities of 60(36.4%), 31(18.8%), 28(17.0%), 28(17.0%), 24(14.5%), 13 (7.9%), 11( 6.7%), and
3(1.8%), respectively. Notably, E. coli was isolated more frequently from female patients (72.7%) than from male patients (27.3%).
Conclusion: Current study revealed that antibiotic resistance is emerging in E coli. However, Colistin, Fosfomycin, Imipenem, Meropenem, and Nitrofurantoin are the most effective drugs and, depending on the clinical situation, can be chosen empirically for the treatment of UTI caused by E. coli.
Key words: Urinary tract infections, E. Coli, Sensitivity pattern
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Copyright (c) 2025 ALMAS IQBAL, Sadia Ijaz, Marium Danish Iqbal, Muhammad Masood Afzal, Asma Ijaz (Author)
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