Adverse Effects of Typbar-Typhoid Conjugated Vaccine Among Children Vaccinated in University of Lahore Teaching Hospital

Abstract

Abstract
Background and Objectives: Rising incidence of XDR enteric fever in Pakistan requires extensive workup
on safe availability of immunization. Aim of this study was to assess the frequency of adverse effects of Typbar
TCVin children vaccinated in a tertiary care facility.
Methods: It was a descriptive study in which children aged 9 months to 15 years of age either gender coming
for vaccination to paediatric opd from 1st Feb-2021 to 17th Feb-2021 were included. Post vaccination
observation for 30 minutes was done for all children in hospital and were followed after 14 days on telephone
for any local or systemic adverse effect after vaccination. Complications (systemic and local) were documented
on proforma. All data were analyzed using SPSS 22.
Results: In ourstudy, total 835 children were enrolled out of which 666 responded. Contact with 169 children
was not possible because their lack of response and unavailability. Mean age was 4.9±4.06 years. Regarding
local adverse effects, pain at site of injection was present in 30% children. Other local site reaction includes
swelling in 17.7%, redness in 3% and limitation of movement in 2.4%. Systemic adverse effects included
fever in 20.4%. Headache was present in 0.6% children, GI symptoms present in 0.9%.
Conclusion: With Typbar-TCV Typhoid Vi conjugate vaccine. fever, pain and local reactogenicity were the
most common side effects. Safety profile of TCV can further be assessed with the help of large multi centre
trials So Tybar –TCV Typhoid Vi conjugate vaccine can be encouraged to administered safely to all children
as the incidence of XDR typhoid is rising.
KeyWord: Conjugate vaccine, adverse effect, Enteric fever