Comparison of Pentraxin-3 in Migraine Patients Without Aura and Healthy Controls

Abstract

Abstract
Background and Objectives: Migraine is a common cerebrovascular conditionmarked by one-sided, pulsating
headache, which may or may not be accompanied with an aura. Migraine is mostly found in females who are
of childbearing age. One of the speculated mechanisms for the pathophysiology of migraine is endothelial
dysfunction.Anew biomarker of inflammatory disorders, pentraxin-3 is often produced by endothelium injury.
In earlier investigations, it was shown that migraine sufferers had elevated levels of pentraxin-3. Our study's
objectiveswere toanalyze the serumpentraxin-3levelsinmigraine suffererswithout aura and healthycontrols.
Methods: It was a cross-sectional comparative study. This was done at the IMBB Department, University of
Lahore, Lahore Pakistan, from March 2020 to April 2022. We took 40 diagnosed migraine cases and 40
healthy controls. Detailed examination was done and proformas were filled by both cases and controls. Serum
was collected by each of them and pentraxin-3 values were determined by using specific Elisa kits. SPSS
version 22 was used for statistical analysis. For normality of data Shapiro wilk test was used. Mann whiteny U
test was used for the comparision of means of pentraxin-3 in migrainers and healthy controls.
Results: The data were non-normally distributed after the Shapiro-Wilk Test. The average age of the controls
was 25±6.06 years, while that of individuals with migraines was 26±7.78 years. Patients with migraine were
mostly women. The majority of the patients had BMI category 18 to 24.5. Patients with migraine had mean
pentraxin-3 levels of 145.75 ±157.7 pg/l, compared to 43.65 ±33.01 pg/l in the control group. Median was
100.5 in cases and 31.15 in controls. P-value was 0.0001.
Conclusion: When compared to the control group, migraine patients had considerably higher blood levels of
PTX-3, and no correlations between age, BMI, marital status, smoking history, and usage of preventative
medications were found.
Key words: migraine, pentraxin-3, endothelial dysfunction, C-reactive protein (CRP),